Honnanayakanavar, Jyoti M.; Nanubolu, Jagadeesh Babu; Suresh, Surisetti published the artcile< Tandem copper catalyzed regioselective N-arylation-amidation: synthesis of angularly fused dihydroimidazoquinazolinones and the anticancer agent TIC10/ONC201>, Computed Properties of 3959-07-7, the main research area is fused tricyclic dihydroimidazoquinazolinone preparation regioselective; aminoimidazoline carboxylic acid arylation amidation cyclocondensation copper catalyst.
Herein, a copper-catalyzed tandem reaction of 2-aminoimidazolines I (R = n-Bu, Ph, furan-2-ylmethyl, pyridin-4-ylmethyl, etc.) and ortho-halo(hetero)aryl carboxylic acids R1C(O)OH (R1 = 2-bromophenyl, 2-bromo-4,5-difluorophenyl, 2-bromopyridin-3-yl, 4-chloropyridin-3-yl, etc.) that causes the regioselective formation of angularly fused tricyclic 1,2-dihydroimidazo[1,2-a]quinazolin-5(4H)-one derivs II (R2 = H, OMe, F; R3 = H, OMe, Cl, Br, F, NO2; R4 = H, F), III and IV was presented. The reaction involved in the construction of the core six-membered pyrimidone moiety proceeded via regioselective N-arylation-condensation. The presented protocol has been successfully applied to accomplish the total synthesis of TIC10/ONC201 V, which is an active angular isomer acting as a tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL): a sought after anticancer clin. agent.
Organic & Biomolecular Chemistry published new progress about Amidation (regioselective). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Computed Properties of 3959-07-7.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary