Hayashi, Yujiro; Hatano, Yutaro; Mori, Naoki published the artcile< Asymmetric Michael Reaction of Malononitrile and α,β-Unsaturated Aldehydes Catalyzed by Diarylprolinol Silyl Ether>, Electric Literature of 3893-18-3, the main research area is diarylprolinol silyl ether preparation; malononitrile unsaturated aldehyde asym Michael.
An asym. Michael reaction of malononitrile and α,β-unsaturated aldehydes catalyzed by a diarylprolinol silyl ether (NC)2CHCH(R)CH2CH(OMe)2 [R = Me, Ph, 2-furyl, etc.] was developed. Michael products were obtained in good yields and with excellent enantioselectivities without the formation of overreaction products. As a malononitrile moiety can be transformed into an alkoxy or amino carbonyl moiety by oxidative transformation, α-chiral esters or amides with all-carbon quaternary centers can be synthesized with excellent enantioselectivities.
Synlett published new progress about Michael reaction. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Electric Literature of 3893-18-3.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary