Geng, Zhi-Cong; Zhang, Shao-Yun; Li, Nai-Kai; Li, Ning; Chen, Jian; Li, Hai-Yan; Wang, Xing-Wang published the artcile< Organocatalytic Diversity-Oriented Asymmetric Synthesis of Tricyclic Chroman Derivatives>, Application In Synthesis of 3893-18-3, the main research area is diphenylprolinol trimethylsilyl ether catalyst Michael aldol Diels Alder reaction; hydroxyaryloxobutenoate enal aldol Diels Alder reaction; organocatalytic diversity oriented asym synthesis tricyclic chroman derivative.
The tandem oxo-Michael-IED/HDA (inverse-electron-demand hetero-Diels-Alder) and oxo-Michael-IED/HDA-Michael-Aldol condensation transformations between (E)-2-hydroxyaryl-2-oxobut-3-enoate derivatives with enals have been developed in the presence of (S)-diphenylprolinol trimethylsilyl ether as an organocatalyst. Two types of tricyclic chroman derivatives, e.g. I and II, were, resp., obtained, by adjusting the reactant ratio and reaction temperature, in good yields (up to 96%) with excellent enantioselectivities (up to >99%) and good diastereoselectivities (up to >30/1). It should be noted that the divergent chiral chroman derivatives were obtained by successive reaction of (E)-2-hydroxyaryl-2-oxobut-3-enoate derivatives with two different enal substrates in highly catalytic results.
Journal of Organic Chemistry published new progress about Aldol condensation. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Application In Synthesis of 3893-18-3.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary