Choi, Anthony; Meijer, Anthony J. H. M.; Silvestri, Ilaria Proietti; Coldham, Iain published the artcile< Kinetic Resolution of 2-Aryl-4-methylenepiperidines toward Enantioenriched Functionalizable Piperidine Fragments>, Recommanded Product: 3-Bromobenzotrifluoride, the main research area is disubstituted piperidine preparation enantioselective; aryl methylenepiperidine kinetic resolution deprotonation.
The base n-BuLi with sparteine allows a kinetic resolution of N-Boc-2-aryl-4-methylenepiperidines. The 2,2-disubstituted products and recovered starting materials were isolated with high enantiomer ratios. From VT-NMR spectroscopy and DFT studies, the rate of rotation of the N-Boc group is fast. Lithiation and trapping of the enantioenriched starting materials gave 2,2-disubstituted piperidines with retention of stereochem. Functionalization of the 4-methylene group led to a variety of 2,4-disubstituted piperidines without loss of enantiopurity that could be useful building blocks for drug discovery.
Journal of Organic Chemistry published new progress about Deprotonation. 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, Recommanded Product: 3-Bromobenzotrifluoride.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary