Chen, Wei-Li; Li, Kun; Liao, Wei-Cong; Liang, Wang-Fu; Qiu, Pei-Wen; Liang, Cui; Su, Gui-Fa; Mo, Dong-Liang published the artcile< An iron(III)-catalyzed dehydrogenative cross-coupling reaction of indoles with benzylamines to prepare 3-aminoindole derivatives>, Category: bromides-buliding-blocks, the main research area is amino indole derivative green preparation diastereoselective; indole benzylamine dehydrogenative cross coupling iron catalyst.
A green cascade approach to prepare a variety of 3-aminoindole derivatives I [R1 = H, 7-Me, 6-Cl, etc.; R2 = H, Me; R3 = Ph, 3-BrC6H4, 2-naphthyl, etc.; R4 = Ph, 2-FC6H4, 3-pyridyl, etc.; R5 = H, Et, Ph] in good to excellent yields through an iron(III)-catalyzed dehydrogenative cross-coupling reaction of 2-arylindoles and primary benzylamines under mild reaction conditions was reported. The reaction showed a broad substrate scope of indoles and benzylamines and tolerated a wide range of functional groups. Moreover, the reaction was easily performed at the gram scale without producing waste after the reaction was completed. The present method highlighted readily available starting materials, a simple purification procedure and the usage of cheap, nontoxic and environmentally benign iron(III) catalyst.
Green Chemistry published new progress about Aromatic amines Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Category: bromides-buliding-blocks.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary