Cao, Qingxiang; Luo, Jie; Zhao, Xiaodan published the artcile< Chiral Sulfide Catalysis for Desymmetrizing Enantioselective Chlorination>, Recommanded Product: (2,6-Dibromophenyl)methanol, the main research area is chiral sulfide catalyzed desymmetrizing enantioselective chlorination aryl olefin; tetralin enantioselective diastereoselective synthesis; tricyclic hexahydrophenalene enantioselective diastereoselective synthesis; spiro nitrogen heterocycle synthesis; Lewis base catalysis; chlorination; cyclizations; olefins; synthetic methods.
An unprecedented chiral sulfide catalyzed desymmetrizing enantioselective chlorination is disclosed. Various aryl-tethered diolefins and diaryl-tethered olefins afforded tetralins and tricyclic hexahydrophenalene derivatives, resp., bearing multiple stereogenic centers in high yields with excellent enantio- and diastereoselectivities [e.g., I → II (91%, 93% ee, 31:1 d.r.) in presence of sulfide III, DCDMH as Cl+ reagent and Tf2NH as acid in CH2Cl2]. In contrast, the tertiary amine catalyst (DHQD)2PHAL led to a diastereomeric product. The products could be transformed into a variety of compounds, such as spiro-N-heterocycles.
Angewandte Chemie, International Edition published new progress about Alkadienes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (aryl-tethered diolefins). 1013031-65-6 belongs to class bromides-buliding-blocks, and the molecular formula is C7H6Br2O, Recommanded Product: (2,6-Dibromophenyl)methanol.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary