Binder, Jorg T.; Cordier, Christopher J.; Fu, Gregory C. published the artcile< Catalytic Enantioselective Cross-Couplings of Secondary Alkyl Electrophiles with Secondary Alkylmetal Nucleophiles: Negishi Reactions of Racemic Benzylic Bromides with Achiral Alkylzinc Reagents>, Reference of 405931-46-6, the main research area is secondary benzylic bromide cycloalkylzinc reagent nickel catalyzed Negishi coupling; chiral isoquinoline oxazoline ligand stereoselective Negishi coupling; acyclic alkylzinc reagent Negishi cross coupling isomerization.
The authors have developed a nickel-catalyzed method for the asym. cross-coupling of secondary electrophiles with secondary nucleophiles, specifically, stereoconvergent Negishi reactions of racemic benzylic bromides with achiral cycloalkylzinc reagents. In contrast to most previous studies of enantioselective Negishi cross-couplings, tridentate pybox ligands are ineffective in this process; however, a new, readily available bidentate isoquinoline-oxazoline ligand I furnishes excellent ee’s and good yields. Ent-I is also used to provide products of opposite configuration with excellent ee’s and good yields. The use of acyclic alkylzinc reagents as coupling partners led to the discovery of a highly unusual isomerization that generates a significant quantity of a branched cross-coupling product from an unbranched nucleophile.
Journal of the American Chemical Society published new progress about Aralkyl bromides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (secondary). 405931-46-6 belongs to class bromides-buliding-blocks, and the molecular formula is C8H8BrF, Reference of 405931-46-6.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary