Afewerki, Samson; Breistein, Palle; Pirttila, Kristian; Deiana, Luca; Dziedzic, Pawel; Ibrahem, Ismail; Cordova, Armando published the artcile< Catalytic Enantioselective β-Alkylation of α,β-Unsaturated Aldehydes by Combination of Transition-Metal- and Aminocatalysis: Total Synthesis of Bisabolane Sesquiterpenes>, Recommanded Product: 3-(4-Bromophenyl)acrylaldehyde, the main research area is bisabolane sesquiterpene curcumene tumerone dehydrocurcumene enantioselective synthesis; unsaturated aldehyde asym beta alkylation.
The first example of enantioselective β-alkylation of α,β-unsaturated aldehydes by combination of aminocatalysis and transition-metal catalysis is reported. The catalyzed asym. 1,4-addition gave the corresponding β-alkyl aldehydes with up to 98:2 e.r. Thus, simple bench stable chiral amines can be used as catalyst in combination with a copper salt without the use of a glove box to achieve catalytic asym. addition of dialkylzinc reagents to enals with high enantioselectivity. The novel co-catalytic reaction was utilized as the key step for the expeditious total synthesis of bisabolane sesquiterpenes, e.g. I.
Chemistry – A European Journal published new progress about 1,4-Addition reaction. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Recommanded Product: 3-(4-Bromophenyl)acrylaldehyde.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary