Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 90-59-5, formula is C7H4Br2O2, Name is 3,5-Dibromo-2-hydroxybenzaldehyde. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Electric Literature of 90-59-5.
Devi, Jai;Pachwania, Sushila;Kumar, Deepak;Jindal, Deepak Kumar;Jan, Suraya;Dash, Ashutosh K. research published 《 Diorganotin(IV) complexes derived from thiazole Schiff bases: synthesis, characterization, antimicrobial and cytotoxic studies》, the research content is summarized as follows. Organotin(IV) complexes are gaining major attention as drug candidates, accordingly we have synthesized a cluster of novel diorganotin(IV) complexes I (R32SnClL; R3 = Me, Et, Bu, Ph; R = H, Br; R1 = H, OH; R2 = NO2, Br) of the corresponding Schiff base ligands (HL1-HL4). The structural elucidation of the compounds was done by using different spectroscopic techniques (UV-Vis, FT-IR, 1H, 13C and 119Sn NMR), mass spectrometry, m.p. and molar conductance measurement. The spectroscopic data recommend that Schiff bases are N,O-bidentate in nature and bind to tin metal via azomethine nitrogen, phenolic oxygen atom and create pentacoordinated environment around central tin metal. To check the biol. utility, the synthesized compounds were tested for antimicrobial activity against different bacterial and fungal strains using serial dilution method and inhibitory activity noted in terms of MIC values (μmol/mL) which displayed that the complexes were more efficient than corresponding Schiff bases and complex 20 (Ph2SnClL4) was most active antimicrobial agent. The compounds were also evaluated for cytotoxic activity against human cancer cell lines- A549 (Lung), PC-3 (Prostate), MDA-MB-231 (Breast), MIA PaCa-2 (pancreas) and human normal cell line fR2 by using MTT method. The results of cytotoxic activity showed that some compounds are active and compounds 10 and 11 (R = H, R1 = OH, R2 = H, R3 = Et, Bu) having IC50 values ranging from 0.01 to 1.42μM are almost equally potent to the standard drug doxorubicin against all examined cell lines and are even less toxic against normal cell line. Diorganotin(IV) complexes of 4-(4-bromophenyl)thiazol-2-amine and salicylaldehyde derivatives were synthesized and exhibited high antibacterial and antitumor activity.
90-59-5, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.
3,5-Dibromosalicylaldehyde, also known as 3,5-Dibromosalicylaldehyde, is a useful research compound. Its molecular formula is C7H4Br2O2 and its molecular weight is 279.91 g/mol. The purity is usually 95%.
3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes. 3,5-Dibromosalicylaldehyde can be used in the synthesis of Schiff base and can be used as reactant for synthesis of Schiff base ligands which forms mononuclear complexes with copper(II), nickel(II), zinc(II) and cobalt(II).
3,5-Dibromosalicylaldehyde is a copper complex that has been synthesized from 3,5-dibromosalicylaldehyde and copper chloride. FTIR spectroscopy revealed that the coordination geometry of the copper complex is octahedral with two nitrogen atoms in the equatorial plane. The presence of hydrogen bonding interactions was confirmed by homologous protein adsorption experiments. This chemical structure was determined using X-ray crystallography and fluorescence probe experiments. The copper complex showed high affinity for malonic acid, which is an ester hydrochloride. The molecular mechanism of this interaction is based on adsorption, which occurs through hydrogen bonding interactions and hydrophobic interactions. Structural analysis revealed that the polymeric matrix consists of a three-dimensional network of crosslinked chains, while FTIR analysis indicated a possible disulfide bond between two cysteine residues., Electric Literature of 90-59-5
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary