A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 70-23-5, formula is C5H7BrO3, Name is Ethyl 3-bromo-2-oxopropanoate. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Name: Ethyl 3-bromo-2-oxopropanoate.
Damghani, Tahereh;Hadaegh, Saba;khoshneviszadeh, Mahsima;Pirhadi, Somayeh;Sabet, Razieh;Khoshneviszadeh, Mehdi;Edraki, Najmeh research published 《 Design, synthesis, in vitro evaluation and molecular docking study of N’-arylidene imidazo[1,2-a]pyridine -2-carbohydrazide derivatives as novel tyrosinase inhibitors》, the research content is summarized as follows. A novel series of imidazo[1,2-a]pyridine 2-carbohydrazide derivatives bearing different arylidene pendants I [R = 4-OH, 2-MeO, 3-OH-4-MeO, etc.] were designed, synthesized and evaluated for their inhibitory activity against mushroom tyrosinase. It was found that compounds I [R = 3-NO2, 4-OH] exhibited the best tyrosinase inhibitory activity with IC50 values of 7.19 and 8.11μM, resp. These results were comparable to that of kojic acid as the reference drug (IC50 = 9.64±0.5μM). Addnl., mol. docking anal. was performed to study the interactions and binding modes of compounds I [R = 3-NO2, 4-OH, 2,4-di-OH] which showed the potential of two critical pi-pi interactions with His263 and Phe264 in the active site of tyrosinase. The results indicated that compounds I [R = 3-NO2, 4-OH] could be introduced as potent tyrosinase inhibitors that might serve as promising candidates in medicine, cosmetics or food industry.
Name: Ethyl 3-bromo-2-oxopropanoate, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.
Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.
Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., 70-23-5.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary