Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 585-76-2, formula is C7H5BrO2, Name is 3-Bromobenzoic acid. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Application of C7H5BrO2.
Dai, Rongke;Li, Tao;Xiao, Shengnan;Chen, Yu;Gao, Jiaming;Su, Guangyue;Zhao, Yuqing research published 《 Synthesis of panaxadiol thiadiazole derivatives and study on its potential cell cycle arrest》, the research content is summarized as follows. In this study, panaxadiol (PD) derivs, I [R1 = 2-Me, 3-O2N, 3,4,5-trimethoxy, etc.] and II [R2 = H, AcO] were designed and synthesized by the reaction of thiadiazoles with PD. The identity of all final products I and II was elucidated by 1H, 13C NMR, HR-MS. The cytotoxicity activities of the derivatives I and II were evaluated against four cancer cell lines using the MTT assay which revealed they indicated excellent anticancer activity. Among these compounds, II [R2 = H] had the most significant cytotoxicity and distinctly inhibited the growth of a variety of tumor cells. Further studies showed that compound II [R2 = H] could decrease the expression levels of CDKs protein family and Cyclin D1 in A549, suggesting that compound II [R2 = H] could block the cell cycle. To prove the above conclusions, the binding sites of the two proteins were simulated by mol. docking method. The results demonstrated that the docking scores of II [R2 = H] and the two cyclins are higher than that of PD. Based on the complex of the target protein and ligand, it was speculated that the enhanced antiproliferative activity may be related to the increased hydrogen bonding interactions. Therefore, these data provide a reference that compound II [R2 = H] could be a promising lead drug for cancer treatment.
585-76-2, 3-bromobenzoic acid is a bromobenzoic acid carrying a single bromo subsituent at the 3-position.
3-Bromobenzoic acid, also known as 3-Bromobenzoic acid, is a useful research compound. Its molecular formula is C7H5BrO2 and its molecular weight is 201.02 g/mol. The purity is usually 95%.
3-bromobenzoic acid is used as a reagent in the synthesis of deoxypodophyllotoxin derivatives with insecticidal activity. Also used as a reagent in the synthesis of thiazole derivatives with antibacterial activity.
3-bromobenzoic acid is a molecule that is classified as a Group P2. It has an electronegativity of 1.3 and an acidity of 0.8, which are both in the middle range of values for this group. 3-Bromobenzoic acid is soluble in water and is soluble in ethanol, acetone, and ether. The chemical structure of 3-bromobenzoic acid can be determined by its monoclonal antibody binding sites, electrochemical impedance spectroscopy data, and Langmuir adsorption isotherm data. 3-Bromobenzoic acid reacts with hydrochloric acid to form benzoate and HCl gas. Chronic exposure to 3-bromobenzoic acid has been shown to cause glutamate dehydrogenase inhibition, leading to an accumulation of p-hydroxybenzoic acid in the body. , Application of C7H5BrO2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary