Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 5445-17-0, formula is C4H7BrO2, Name is Methyl 2-bromopropanoate. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Application In Synthesis of 5445-17-0.
Corbin, Daniel A.;Puffer, Katherine O.;Chism, Katherine A.;Cole, Justin P.;Theriot, Jordan C.;McCarthy, Blaine G.;Buss, Bonnie L.;Lim, Chern-Hooi;Lincoln, Sarah R.;Newell, Brian S.;Miyake, Garret M. research published 《 Radical Addition to N,N-Diaryl Dihydrophenazine Photoredox Catalysts and Implications in Photoinduced Organocatalyzed Atom Transfer Radical Polymerization》, the research content is summarized as follows. Photoinduced organocatalyzed atom transfer radical polymerization (O-ATRP) is a controlled radical polymerization methodol. catalyzed by organic photoredox catalysts (PCs). In an efficient O-ATRP system, good control over mol. weight with an initiator efficiency (I* = Mn,theo/Mn,exp x 100%) near unity is achieved, and the synthesized polymers possess a low dispersity (D). N,N-Diaryl dihydrophenazine catalysts typically produce polymers with low dispersity (D < 1.3) but with less than unity mol. weight control (I* ~60-80%). This work explores the termination reactions that lead to decreased control over polymer mol. weight and identifies a reaction leading to radical addition to the phenazine core. This reaction can occur with radicals generated through reduction of the ATRP initiator or the polymer chain end. In addition to causing a decrease in I*, this reactivity modifies the properties of the PC, ultimately impacting polymerization control in O-ATRP. With this insight in mind, a new family of core-substituted N,N-diaryl dihydrophenazines is synthesized from com. available ATRP initiators and employed in O-ATRP. These new core-substituted PCs improve both I* and D in the O-ATRP of MMA, while minimizing undesired side reactions during the polymerization Further, the ability of one core-substituted PC to operate at low catalyst loadings is demonstrated, with minimal loss of polymerization control down to 100 ppm (weight average mol. weight [Mw] = 10.8 kDa, D = 1.17, I* = 104% vs. Mw = 8.26, D = 1.10, I* = 107% at 1000 ppm) and signs of a controlled polymerization down to 10 ppm of the catalyst (Mw = 12.1 kDa, D = 1.36, I* = 107%).
5445-17-0, Methyl 2-bromopropionate, also known as Methyl 2-bromopropionate, is a useful research compound. Its molecular formula is C4H7BrO2 and its molecular weight is 167 g/mol. The purity is usually 95%.
Methyl 2-bromopropionate is used in the synthesis of poly(ADP-Ribose)polymerase inhibitors derived from benzoxazin-3-one. Also used in the synthesis of 5-HT2C antagonists affecting serotonin levels.
Methyl 2-bromopropanoate is a chemical compound that can be synthesized in an asymmetric manner. The reaction of methyl 2-bromopropanoate with hydrochloric acid gives the corresponding carboxylic acid, methyl propanoate, and hydrogen bromide in a 1:1 ratio. It has been shown that methyl 2-bromopropanoate is a potential catalyst for the reduction of chloride to chloride ion via the borohydride reduction method. Methyl 2-bromopropanoate has also been used as a model system for studying halides and copper complexes. Magnetic resonance spectroscopy studies have revealed that this chemical compound has a high redox potential and kinetic properties., Application In Synthesis of 5445-17-0
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary