Cho, Nobuo team published research on Bioorganic & Medicinal Chemistry in 2022 | 5445-17-0

Product Details of C4H7BrO2, Methyl 2-bromopropionate, also known as Methyl 2-bromopropionate, is a useful research compound. Its molecular formula is C4H7BrO2 and its molecular weight is 167 g/mol. The purity is usually 95%.
Methyl 2-bromopropionate is used in the synthesis of poly(ADP-Ribose)polymerase inhibitors derived from benzoxazin-3-one. Also used in the synthesis of 5-HT2C antagonists affecting serotonin levels.
Methyl 2-bromopropanoate is a chemical compound that can be synthesized in an asymmetric manner. The reaction of methyl 2-bromopropanoate with hydrochloric acid gives the corresponding carboxylic acid, methyl propanoate, and hydrogen bromide in a 1:1 ratio. It has been shown that methyl 2-bromopropanoate is a potential catalyst for the reduction of chloride to chloride ion via the borohydride reduction method. Methyl 2-bromopropanoate has also been used as a model system for studying halides and copper complexes. Magnetic resonance spectroscopy studies have revealed that this chemical compound has a high redox potential and kinetic properties., 5445-17-0.

Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 5445-17-0, formula is C4H7BrO2, Name is Methyl 2-bromopropanoate. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Product Details of C4H7BrO2.

Cho, Nobuo;Kikuzato, Ko;Futamura, Yushi;Shimizu, Takeshi;Hayase, Hiroki;Kamisaka, Kikuko;Takaya, Daisuke;Yuki, Hitomi;Honma, Teruki;Niikura, Mamoru;Kobayashi, Fumie;Watanabe, Nobumoto;Osada, Hiroyuki;Koyama, Hiroo research published 《 New antimalarials identified by a cell-based phenotypic approach: Structure-activity relationships of 2,3,4,9-tetrahydro-1H-β-carboline derivatives possessing a 2-((coumarin-5-yl)oxy)alkanoyl moiety》, the research content is summarized as follows. The identification, structure-activity relationships (SARs) and biol. effects of new antimalarials I [R = Me, Et, cyclopropylmethyl, etc.; R1 = Me, Et, Pr, etc.; R2 = H; R3 = C(O)OMe, C(O)Me, C(O)NHMe, etc.; R4 = H, Me, morpholin-4-yl] consisting of a 2,3,4,9-tetrahydro-1H-β-carboline core, a coumarin ring and an oxyalkanoyl linker was described. A cell-based phenotypic approach was employed in this search for novel antimalarial drugs with unique modes of action. This screening campaign of the RIKEN compound library succeeded in the identification of the known tetrahydro-β-carboline derivative I [R = n-Bu, R1 = H, R2 = H, R3 = C(O)OMe, R4 = Me] as a hit compound showing significant in vitro activity. SAR studies on this chem. series led to the discovery of compound I [R = n-Bu, R1 = (R)-Me, R2 = H, R3 = (S)-C(O)OMe, R4 = Me] having a (R)-Me group on the oxyacetyl linker with potent inhibition of parasite growth (IC50 = 2.0 nM). Compound I [R = n-Bu, R1 = (R)-Me, R2 = H, R3 = (S)-C(O)OMe, R4 = Me] was also found to exhibit significant in vivo antimalarial effects in mouse models. Furthermore, mol. modeling studies on compounds I [R = n-Bu, R1 = H, (R/S)-Me, R2 = H, R3 = (S)-C(O)OMe, R4 = Me] suggested that the (R)-Me group of 4h forces the preferential adoption of a specific conformer which was considered to be an active conformer.

Product Details of C4H7BrO2, Methyl 2-bromopropionate, also known as Methyl 2-bromopropionate, is a useful research compound. Its molecular formula is C4H7BrO2 and its molecular weight is 167 g/mol. The purity is usually 95%.
Methyl 2-bromopropionate is used in the synthesis of poly(ADP-Ribose)polymerase inhibitors derived from benzoxazin-3-one. Also used in the synthesis of 5-HT2C antagonists affecting serotonin levels.
Methyl 2-bromopropanoate is a chemical compound that can be synthesized in an asymmetric manner. The reaction of methyl 2-bromopropanoate with hydrochloric acid gives the corresponding carboxylic acid, methyl propanoate, and hydrogen bromide in a 1:1 ratio. It has been shown that methyl 2-bromopropanoate is a potential catalyst for the reduction of chloride to chloride ion via the borohydride reduction method. Methyl 2-bromopropanoate has also been used as a model system for studying halides and copper complexes. Magnetic resonance spectroscopy studies have revealed that this chemical compound has a high redox potential and kinetic properties., 5445-17-0.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary