Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 402-49-3, formula is C8H6BrF3, Name is 1-(Bromomethyl)-4-(trifluoromethyl)benzene. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Application of C8H6BrF3.
Cadena, Melissa;Villatoro, Roberto Silva;Gupta, Jyoti Shah;Phillips, Cody;Allen, Jonathan B.;Arman, Hadi D.;Wherritt, Daniel J.;Clanton, Nicholas A.;Ruchelman, Alexander L.;Simmons, Eric M.;DelMonte, Albert J.;Coombs, John R.;Frantz, Doug E. research published 《 Pd-Catalyzed Chemoselective O-Benzylation of Ambident 2-Quinolinone Nucleophiles》, the research content is summarized as follows. A highly chemoselective O-benzylation of ambident 2-quinolinone nucleophiles via Pd-catalysis was discovered and demonstrated. Detailed reaction anal. using direct-injection high resolution mass spectrometry (DI-HRMS) combined with in situ 31P NMR implicate a phosphine mono-oxide Pd(II) η1-benzyl complex as a key intermediate on the catalytic cycle. Extrapolation of this method to selectively O-alkylate a series of substituted 2-quinolinones using several benzylic electrophiles was demonstrated providing 2-benzyloxy quinolines in good yields and high O:N selectivities (up to 100:1) utilizing as little as 1 mol % Pd-catalyst to achieve these results.
402-49-3, 4-Trifluoromethylbenzyl bromide is a useful research compound. Its molecular formula is C8H6BrF3 and its molecular weight is 239.03 g/mol. The purity is usually 95%.
4-Trifluoromethylbenzyl bromide is a choline derivative that acts as an anticancer agent. It is structurally similar to the anticancer drug doxorubicin, which has been shown to be effective against breast cancer and leukemia. 4-Trifluoromethylbenzyl bromide interacts with cellular proteins, including choline kinase, and inhibits the mitochondrial pathway. This leads to cell death through apoptosis. The molecule also interacts with nucleotide bases such as thymine and cytosine in DNA, inhibiting transcription and replication. 4-Trifluoromethylbenzyl bromide binds strongly to the hydroxyl group of cholesterol by an electrophilic substitution mechanism to form a covalent bond with its hydroxy group. The molecule can also bind to chloride ions by an ionic bond., Application of C8H6BrF3
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary