Computed Properties of C14H21Br2ClN2In 2013, Lee, Tae-Woong;Jeong, Rae-Seok;Jeong, Seung-A.;Kim, Jeong-Hyun;Shim, Young-Hun;Kim, In-Kyu;Park, Chang-Won published 《Development of dissolution test method for acebrophylline capsules and bromhexine hydrochloride tablets in Korean pharmaceutical codex》. 《Yakhak Hoechi》published the findings. The article contains the following contents:
Although the dissolution test can serve as an effective tool for quality control and predictor of in vivo performance, there are a number of drugs with no established dissolution specification in Korean Pharmaceutical Codex (KPC). So, with each reference and test drugs, the dissolution test method and an anal. procedure by HPLC were developed and validated to establish dissolution specification for acebrophylline capsules and bromhexine hydrochloride tablets. The dissolution condition was determined based on the “Guidelines on Specifications of Dissolution tests for Oral dosage forms” of Ministry of Food and Drug Safety (MFDS). The anal. method of HPLC was validated in specificity, linearity, precision and accuracy. Final dissolution test was performed with com. available samples of 3 lots to establish specification. In addition, no difference was observed by the inter-laboratory evaluation. Dissolution specifications and conditions will be used for revising the monograph of acebrophylline capsules and bromhexine hydrochloride tablets in next supplement of KPC. To complete the study, the researchers used 2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride (cas: 611-75-6) .
2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride(cas: 611-75-6) is intended to support the body’s mechanisms for clearing mucus from the respiratory tract. Bromhexine is a synthetic derivative of the herbal active ingredient vasicine. It has been shown to increase the proportion of serous bronchial secretion, making it more easily expectorated. It is indicated as secretolytic therapy in bronchopulmonary diseases associated with abnormal mucus secretion and impaired mucus transport.Computed Properties of C14H21Br2ClN2
Reference:
Bromide – Wikipedia,
bromide – Wiktionary