COA of Formula: C14H21Br2ClN2In 2016, Li, Wendong;Wang, Chenggang;Wu, Kechun;Liu, Haitao;Wang, Junqiu published 《Comparative study on domestic bromhexine hydrochloride tablets and primary research preparation》. 《Zhongguo Yaoshi (Beijing, China)》published the findings. The article contains the following contents:
Objective: To evaluate the quality of domestic bromhexine hydrochloride tablets and primary research preparations Methods: The dissolution curves of the tablets and preparation in four dissolution media were compared. The quality of Bromhexine Hydrochloride Tablets was analyzed with the new related substances method. Results: The comparative study showed the dissolution curve of one domestic manufacturer was similar to that of the original manufacturer. Impurity profiles anal. showed that unknown impurity X which came from API was the main reason to influence the purity level of domestic preparations, meanwhile, impurity X was not detected in primary research preparations Conclusion: The quality of API was the main factor to influence the quality of domestic preparations There was difference in manufacturing technique between foreign API and domestic API.2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride (cas: 611-75-6) were involved in the experimental procedure.
2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride(cas: 611-75-6) is a mucolytic agent that exerts both a secretagogic action on submucosal glands and a mucolytic action toward acid glycoproteins inside cells. Bromhexine Hydrochloride is a medication prescribed for coughs which works by dissolving hard phlegm. OthersBromhexine is a mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus. In addition, bromhexine has antioxidant properties. COA of Formula: C14H21Br2ClN2
Reference:
Bromide – Wikipedia,
bromide – Wiktionary