Feng, Guo published 《Improvement of quality standard of compound tulobuterol syrup》 in 2015. The article was appeared in 《Zhongguo Yaoshi (Beijing, China)》. They have made some progress in their research.Product Details of 611-75-6 The article mentions the following:
Objective: To establish a method for the assay of bromhexine hydrochloride and promethazine hydrochloride in compound tulobuterol syrup by HPLC to improve its quality standard Methods: The procedure was performed on the Agilent Eclipse Plus C18 column (250 mm × 4.6 mm, 5 μm) at 30°C, detected at 247 nm. The mobile phase was composed by a gradient of acetonitrile and 0.5% triethylamine solution (35 : 65, of which the pH was adjusted to 3.5 by phosphoric acid, fluxed at 1.0 mL·min-1). Results: Bromhexine hydrochloride and promethazine hydrochloride were in good linear at 7.693-192.320 μg·mL-1 (r = 0.9999), and 4.509-112.720 μg·mL-1 (r = 0.9999), resp. The mean recoveries were 99.43% (RSD = 0.60%), and 99.34% (RSD = 0.64%) (n = 9). Conclusion: The method is proved to be specific, accurate, sensitive, simple and applicable for quality control of this product. And 2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride (cas: 611-75-6) was used in the research process.
2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride(cas: 611-75-6) is intended to support the body’s mechanisms for clearing mucus from the respiratory tract. Bromhexine is a synthetic derivative of the herbal active ingredient vasicine. It has been shown to increase the proportion of serous bronchial secretion, making it more easily expectorated. It is indicated as secretolytic therapy in bronchopulmonary diseases associated with abnormal mucus secretion and impaired mucus transport.Product Details of 611-75-6
Reference:
Bromide – Wikipedia,
bromide – Wiktionary