Sharif, Muhammad;Pews-Davtyan, Anahit;Lukas, Jan;Schranck, Johannes;Langer, Peter;Rolfs, Arndt;Beller, Matthias published 《Palladium-Catalyzed Carbonylative Transformations of Bromhexine into Bioactive Compounds as Glucocerebrosidase Inhibitors》. The research results were published in《European Journal of Organic Chemistry》 in 2014.HPLC of Formula: 611-75-6 The article conveys some information:
A general synthesis for dicarbonylated derivatives of the parent drug bromhexine is described. By using com. available Pd(OAc)2/BuPAd2 [CataCXium A, Ad = adamantyl, (butyl)bis(tricyclo[3.3.1.13,7]dec-1-yl)phosphine] catalyst system, the carbonylative arylation, amination and alkoxylation of bromohexine proceeded with up to 79% product yield. Selected synthesized derivatives of bromhexine showed improved effects as glucocerebrosidase inhibitors. The synthesis of the target compounds was achieved using 2-amino-3,5-dibromo-N-cyclohexyl-N-methylbenzenemethanamine (bromhexine) as a starting material. And 2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride (cas: 611-75-6) was used in the research process.
2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride(cas: 611-75-6) (BHH; 250μM; 24 hours) also significantly attenuates HGF-induced invasion of LNCaP and C4-2B cells that natively express TMPRSS2. No significant toxicity is observed over a 48-hour period exposing LNCaP, DU145, PC3, or HepG2 cells to Bromhexine hydrochloride concentrations ranging from 0μM to 250μM. Bromhexine hydrochloride exposure does not induce cell death or substantially suppress the growth of DU145 cells.Bromhexine hydrochloride (20 μM; 48 h) inhibits dendritic cells infection with HIV-1.HPLC of Formula: 611-75-6
Reference:
Bromide – Wikipedia,
bromide – Wiktionary