Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. 402-49-3, formula is C8H6BrF3, The most pervasive is the naturally produced bromomethane. Electric Literature of 402-49-3
Yin, Wenbo;Cui, Hengxian;Jiang, Hong;Zhang, Yuxin;Liu, Lei;Wu, Tianxiao;Sun, Yin;Zhao, Liyu;Su, Xin;Zhao, Dongmei;Cheng, Maosheng research published 《 Broadening antifungal spectrum and improving metabolic stablity based on a scaffold strategy: Design, synthesis, and evaluation of novel 4-phenyl-4,5-dihydrooxazole derivatives as potent fungistatic and fungicidal reagents》, the research content is summarized as follows. 5-Phenylthiophene derivatives exhibited excellent antifungal activity against Candida albicans, Candida tropicalis and Cryptococcus neoformans. However, optimal compound II was inactive against Aspergillus fumigatus and unstable in human liver microsomes in vitro with a half-life of 18.6 min. To discover antifungal agents with a broad spectrum and improve the metabolic properties of the compounds, the scaffold hopping strategy was adopted and a series of I [R2 = 3-Me, 2-Et, 2-iso-Pr, etc.,] were designed and synthesized. It was especially encouraging that compound I [R = 2-F] displayed significant antifungal activities against eight susceptible strains and seven FLC-resistant strains. Furthermore, the potent compound I [R = 2-F] could prevent the formation of fungalbiofilms and displayed satisfactory fungicidal activity. In addition, the metabolic stability of compound I [R = 2-F] was improved significantly, with the half-life of 70.5 min. Compound I [R = 2-F] was almost nontoxic to mammalian A549, MCF-7, HepG2, and 293T cells. Moreover, pharmacokinetic studies in SD rats showed that compound I [R = 2-F] exhibited pharmacokinetic properties with a bioavailability of 15.22% and a half-life of 4.44 h, indicating that compound I [R = 2-F] is worthy of further study.
402-49-3, 4-Trifluoromethylbenzyl bromide is a useful research compound. Its molecular formula is C8H6BrF3 and its molecular weight is 239.03 g/mol. The purity is usually 95%.
4-Trifluoromethylbenzyl bromide is a choline derivative that acts as an anticancer agent. It is structurally similar to the anticancer drug doxorubicin, which has been shown to be effective against breast cancer and leukemia. 4-Trifluoromethylbenzyl bromide interacts with cellular proteins, including choline kinase, and inhibits the mitochondrial pathway. This leads to cell death through apoptosis. The molecule also interacts with nucleotide bases such as thymine and cytosine in DNA, inhibiting transcription and replication. 4-Trifluoromethylbenzyl bromide binds strongly to the hydroxyl group of cholesterol by an electrophilic substitution mechanism to form a covalent bond with its hydroxy group. The molecule can also bind to chloride ions by an ionic bond., Electric Literature of 402-49-3
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary