Safety of 1,3-Dimesityl-1H-imidazol-3-ium tetrafluoroborate. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 1,3-Dimesityl-1H-imidazol-3-ium tetrafluoroborate, is researched, Molecular C21H25BF4N2, CAS is 286014-53-7, about Continuous-Flow N-Heterocyclic Carbene Generation and Organocatalysis. Author is Di Marco, Lorenzo; Hans, Morgan; Delaude, Lionel; Monbaliu, Jean-Christophe M..
Two methods were assessed for the generation of common N-heterocyclic carbenes (NHCs) from stable imidazol(in)ium precursors using convenient and straightforward continuous-flow setups with either a heterogeneous inorganic base (Cs2CO3 or K3PO4) or a homogeneous organic base (KN(SiMe3)2). In-line quenching with carbon disulfide revealed that the homogeneous strategy was most efficient for the preparation of a small library of NHCs. The generation of free nucleophilic carbenes was next telescoped with two benchmark NHC-catalyzed reactions; namely, the transesterification of vinyl acetate with benzyl alc. and the amidation of N-Boc-glycine Me ester with ethanolamine. Both organocatalytic transformations proceeded with total conversion and excellent yields were achieved after extraction, showcasing the first examples of continuous-flow organocatalysis with NHCs.
Different reactions of this compound(1,3-Dimesityl-1H-imidazol-3-ium tetrafluoroborate)Safety of 1,3-Dimesityl-1H-imidazol-3-ium tetrafluoroborate require different conditions, so the reaction conditions are very important.
Reference:
Bromide – Wikipedia,
bromide – Wiktionary