Shen, Ke; Bai, Bing; Liu, Yu-Hsuan; Lowary, Todd L. published the article 《Synthesis of a Tridecasaccharide Lipooligosaccharide Antigen from the Opportunistic Pathogen Mycobacterium kansasii》. Keywords: antibacterial Mycobacterium kansasii antigen tridecasaccharide pathogen mycobacteria tuberculosis immunomodulator; BSA bovine serum albumin structure activity lipooligosaccharide tridecasaccharide bioconjugate; antigens; complex glycans; lipooligosaccharides; mycobacteria; total synthesis.They researched the compound: 8-Bromooctanoic acid( cas:17696-11-6 ).Category: bromides-buliding-blocks. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:17696-11-6) here.
The outer surfaces of mycobacteria, including the organism that causes tuberculosis, are decorated with an array of immunomodulatory glycans. Among these are lipooligosaccharides (LOSs), a class of mols. for which the function remains poorly understood. We describe the chem. synthesis of the glycan portion of a tridecasaccharide LOS from the opportunistic pathogen Mycobacterium kansasii. The target contains a number of unusual structural motifs that complicate its assembly and is the most complex mycobacterial LOS glycan to be synthesized to date when considering size and number of unique monosaccharides and glycosidic linkages. These studies not only provide a road-map for the preparation of addnl. members of this family of glycans, but also provides a valuable probe for use in structure-activity relationship investigations.
《Synthesis of a Tridecasaccharide Lipooligosaccharide Antigen from the Opportunistic Pathogen Mycobacterium kansasii》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(8-Bromooctanoic acid)Category: bromides-buliding-blocks.
Reference:
Bromide – Wikipedia,
bromide – Wiktionary