Zhang, Lvye; Wu, Binqiang; Chen, Zhangtao; Hu, Jinjin; Zeng, Xiaofei; Zhong, Guofu published the article 《Chiral phosphoric acid catalyzed enantioselective N-alkylation of indoles with in situ generated cyclic N-acyl ketimines》. Keywords: isoindolinylindole preparation enantioselective chemoselective; indole hydroxyisoindolinone phosphoric acid catalyst alkylation.They researched the compound: 6-Bromo-3-methyl-1H-indole( cas:1219741-50-0 ).Application In Synthesis of 6-Bromo-3-methyl-1H-indole. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:1219741-50-0) here.
A chiral SPINOL derived phosphoric acid-catalyzed asym. N-alkylation reaction of indoles with cyclic α-diaryl-substituted N-acyl imines, which are generated in-situ from 3-aryl 3-hydroxyisoindolinones, was demonstrated. The transformation proceeded smoothly with a broad range of indoles and isoindolinone alcs. A variety of indole derived N-alkylated tetrasubstituted chiral aminals were afforded in moderate to good yields (50-79%) with excellent enantioselectivities (up to 98% ee).
《Chiral phosphoric acid catalyzed enantioselective N-alkylation of indoles with in situ generated cyclic N-acyl ketimines》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(6-Bromo-3-methyl-1H-indole)Application In Synthesis of 6-Bromo-3-methyl-1H-indole.
Reference:
Bromide – Wikipedia,
bromide – Wiktionary