The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 7-Chloro-4-(piperazin-1-yl)quinoline, is researched, Molecular C13H14ClN3, CAS is 837-52-5, about Investigation on the synthesis of piperaquine, a component of the antimalarial drug artekin, the main research direction is piperaquine synthesis antimalarial.Category: bromides-buliding-blocks.
Plasmodium falciparum malaria remains a serious endemic disease in many parts of the world. It is estimated that 120 million cases occur worldwide each year, causing over one million deaths. The problem has been compounded by the emergence of strains of P. falciparum resistant to virtually all antimalarial agents. Resistance to chloroquine has now spread to almost all areas where malaria is endemic. Chloroquine-resistant strains are typically cross resistant to all drugs of relative chem. structure, and therefore the need for finding new mols. with novel modes of action is urgent. In an effort to discover active compounds against the chloroquine resistant malaria, several bis(quinolyl)piperazines such as piperaquine have been reported. Piperaquine has been effectively used in combination with dihydroartemisinin for treatment of the CQ-resistant malaria in Vietnam. However, Vietnam is still dependent upon the import of this compound In this article, the authors report the synthesis of piperaquine by reaction of 4,7-dichloroquinoline with N-formylpiperazine, followed by deprotection, and reaction with 1,3-dibromopropane.
Different reactions of this compound(7-Chloro-4-(piperazin-1-yl)quinoline)Category: bromides-buliding-blocks require different conditions, so the reaction conditions are very important.
Reference:
Bromide – Wikipedia,
bromide – Wiktionary