Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 1219741-50-0, is researched, SMILESS is CC1=CNC2=C1C=CC(Br)=C2, Molecular C9H8BrNJournal, ChemCatChem called Chiral Broensted Acid-Catalyzed Asymmetric 1,4-Addition of Benzofuran-Derived Azadienes with 3-Substituted indoles, Author is Zhou, Ji; Li, Tian-Zhen; Sun, Yu-Wen; Du, Bai-Xiang; Tan, Wei; Shi, Feng, the main research direction is methyl indolyl aryl benzofuranyl benzenesulfonamide preparation enantioselective; benzofuranyl azadiene indole asym addition chiral Bronsted acid catalyst.Safety of 6-Bromo-3-methyl-1H-indole.
A chiral phosphoric acid-catalyzed asym. 1,4-addition of benzofuran-derived azadienes I (R = H, 3-F, 4-Cl, 3-Me, etc.) with 3-substituted indoles II (R1 = Me, Et, Bn, Ph, 2-thienyl; R2 = H, 5-Cl, 6-Br, 7-Me, etc.) has been established, which offered enantioenriched tri(hetero)arylmethane products (S)-III in generally good yields (up to 98%) and high enantioselectivities (up to 99:1 er). This reaction has not only realized the application of chiral phosphoric acid as a competent catalyst in the asym. transformations of benzofuran-derived azadienes I, but also has accomplished the task of developing chiral Bronsted acid-catalyzed asym. 1,4-additions of benzofuran-derived azadienes I, which will enrich the research contents of chiral phosphoric acid catalysis and the chem. of benzofuran-derived azadienes I.
《Chiral Broensted Acid-Catalyzed Asymmetric 1,4-Addition of Benzofuran-Derived Azadienes with 3-Substituted indoles》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(6-Bromo-3-methyl-1H-indole)Safety of 6-Bromo-3-methyl-1H-indole.
Reference:
Bromide – Wikipedia,
bromide – Wiktionary