The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Synthesis of new 4-aminoquinolines and quinoline-acridine hybrids as antimalarial agents》. Authors are Kumar, Ashok; Srivastava, Kumkum; Raja Kumar, S.; Puri, S. K.; Chauhan, Prem M. S..The article about the compound:7-Chloro-4-(piperazin-1-yl)quinolinecas:837-52-5,SMILESS:C1=C(Cl)C=C2C(=C1)C(=CC=N2)N3CCNCC3).Formula: C13H14ClN3. Through the article, more information about this compound (cas:837-52-5) is conveyed.
In the present study, new side chain modified 4-aminoquinoline derivatives and quinoline-acridine hybrids were synthesized and evaluated in vitro against NF 54 strain of Plasmodium falciparum. Among the evaluated compounds, one compound (MIC = 0.125 μg/mL) was equipotent to standard drug CQ (MIC = 0.125 μg/mL) and it showed the curative response to all the treated swiss mice infected with CQ-resistant N-67 strain of Plasmodium yoelii at the doses 50 mg/kg and 25 mg/kg for four days by i.p. route and was found to be orally active at the dose of 100 mg/kg for four days. Another compound (MIC = 0.031 μg/mL) was four times more potent than CQ. The promising antimalarial potency of these compounds highlight the significance of exploring the privileged 4-aminoquinoline class for new antimalarials.
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Reference:
Bromide – Wikipedia,
bromide – Wiktionary