The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: (2S)-1-[(4R)-4,5-dihydro-4-phenyl-2-oxazolyl]-2-(diphenylphosphino)ferrocene, is researched, Molecular C31H26FeNOP, CAS is 291536-01-1, about Catalytic Enantioselective Formal Synthesis of MDM2 Antagonist RG7388 and Its Analogues, the main research direction is arylimino acetate enantioselective diastereoselective dipolar cycloaddition cyanostilbene copper catalyst; cyano triaryl pyrrolidine carboxylate asym synthesis; MDM2 antagonist RG7388 formal synthesis.Name: (2S)-1-[(4R)-4,5-dihydro-4-phenyl-2-oxazolyl]-2-(diphenylphosphino)ferrocene.
The catalytic asym. 1,3-dipolar [3 + 2] cycloaddition of azomethine ylides, generated in-situ from imino esters ArCH:NCH2CO2Me (Ar = 4-ClC6H4, 4-BrC6H4, 4-MeC6H4, 2-thienyl, 2-naphthyl), with cyanostilbenes R1C(CN):CHR2 (R1 = Ph, 4-ClC6H4; R2 = Ph, 4-MeC6H4, 3-BrC6H4, etc.) was established, affording structurally diverse pyrrolidines I (and their enantiomers) bearing four contiguous stereocenters with stereo-diversity in generally high yields and good to excellent stereoselectivities (up to 98% yield, 99:1 dr, >99% ee). This strategy allowed the formal synthesis of antitumor drug RG7388 (phase III clin. study) and its analogs in high efficiency.
Although many compounds look similar to this compound(291536-01-1)Name: (2S)-1-[(4R)-4,5-dihydro-4-phenyl-2-oxazolyl]-2-(diphenylphosphino)ferrocene, numerous studies have shown that this compound(SMILES:[H]C12=C3([H])[Fe+2]145678(C3=C94C%10=N[C@H](C%11=CC=CC=C%11)CO%10)([C-]%12C5=C6C7=C8%12)[C-]92P(C%13=CC=CC=C%13)C%14=CC=CC=C%14), has unique advantages. If you want to know more about similar compounds, you can read my other articles.
Reference:
Bromide – Wikipedia,
bromide – Wiktionary