The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 7-Chloro-4-(piperazin-1-yl)quinoline( cas:837-52-5 ) is researched.Related Products of 837-52-5.El-Azzouny, Aida M. Abd El-Sattar; Aboul-Enein, Mohamed Nabil; Hamissa, Mohamed Farouk published the article 《Structural and biological survey of 7-chloro-4-(piperazin-1-yl)quinoline and its derivatives》 about this compound( cas:837-52-5 ) in Drug Development Research. Keywords: review quinoline antiHIV antimalarial antiparasitic agent medicinal chem; 7-chloro-4-(piperazin-1-yl)quinoline; anti-HIV; anticancer; antidiabetic; antimalarial. Let’s learn more about this compound (cas:837-52-5).
A review. The 7-chloro-4-(piperazin-1-yl)quinoline structure is an important scaffold in medicinal chem. It exhibited either alone or as hybrid with other active pharmacophores diverse pharmacol. profiles such as: antimalarial, antiparasitic, anti-HIV, antidiabetic, anticancer, sirtuin Inhibitors, dopamine-3 ligands, acetylcholinesterase inhibitors, and serotonin antagonists. In the presented review, a comprehensive discussion of compounds having this structural core is surveyed and illustrated.
Although many compounds look similar to this compound(837-52-5)Related Products of 837-52-5, numerous studies have shown that this compound(SMILES:C1=C(Cl)C=C2C(=C1)C(=CC=N2)N3CCNCC3), has unique advantages. If you want to know more about similar compounds, you can read my other articles.
Reference:
Bromide – Wikipedia,
bromide – Wiktionary