The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 7-Chloro-4-(piperazin-1-yl)quinoline(SMILESS: C1=C(Cl)C=C2C(=C1)C(=CC=N2)N3CCNCC3,cas:837-52-5) is researched.Formula: C21H25BF4N2. The article 《Antiparasitic agents. Part VI. Synthesis of 7-chloro-4-(4-substituted-phenylamino)- and 7-chloro-4-(4-substituted-piperazin-1-yl)quinolines as potential antiparasitic agents》 in relation to this compound, is published in Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry. Let’s take a look at the latest research on this compound (cas:837-52-5).
Chloro(hydroxyphenylamino)quinolines I (R = H, CO2H, NO2, NH2, substituted carbamoyl, R1 = H, C6H4OMe-2, C6H4Me-3, C6H4Me-4), chloro(4-piperazinyl)quinolines II (R2 = H, substituted carbamoyl, substituted carbamoylmethyl), and other similar compounds were prepared and tested for their antimalarial, antifilarial and antimicrobial activities but none of them shows any noteworthy activity.
Although many compounds look similar to this compound(837-52-5)Electric Literature of C13H14ClN3, numerous studies have shown that this compound(SMILES:C1=C(Cl)C=C2C(=C1)C(=CC=N2)N3CCNCC3), has unique advantages. If you want to know more about similar compounds, you can read my other articles.
Reference:
Bromide – Wikipedia,
bromide – Wiktionary