Zhu, Minghui; Zhang, Qinglong; Zi, Weiwei published the article 《Diastereodivergent Synthesis of β-Amino Alcohols by Dual-Metal-Catalyzed Coupling of Alkoxyallenes with Aldimine Esters》. Keywords: diastereodivergent synthesis beta amino alc; dual metal catalyst coupling alkoxyallene aldimine ester; total synthesis mycestericins F G; amino alcohols; asymmetric catalysis; palladium; stereodivergence; synergistic catalysis.They researched the compound: (2S)-1-[(4R)-4,5-dihydro-4-phenyl-2-oxazolyl]-2-(diphenylphosphino)ferrocene( cas:291536-01-1 ).Related Products of 291536-01-1. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:291536-01-1) here.
Both syn- and anti-β-amino alcs. are common structural motifs in natural products, drug mols., chiral ligands and catalysts. However, the currently available methods for synthesizing these motifs are limited to generate only one diastereoisomer. Therefore, development of a unified method for stereoselective access to complementary diastereomers would be highly desirable. Herein, we report a method for dual-metal-catalyzed diastereodivergent coupling of alkoxyallenes with aldimine esters. By carefully selecting the two metals and appropriate chiral ligands, we could synthesize both syn- and anti-β-amino alc. motifs with high enantioselectivity and diastereoselectivity from the same set of starting materials. Furthermore, stereodivergent syntheses of all four stereoisomers of β-amino alcs. could be achieved. We demonstrated the synthetic utility of this method by concisely synthesizing two β-amino alc. natural products, mycestericins F and G.
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Reference:
Bromide – Wikipedia,
bromide – Wiktionary