So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Ishitani, Haruro; Komiyama, Susumu; Hasegawa, Yoshiki; Kobayashi, Shu researched the compound: (S)-3,3′-Dibromo-1,1′-bi-2-naphthol( cas:119707-74-3 ).SDS of cas: 119707-74-3.They published the article 《Catalytic Asymmetric Strecker Synthesis. Preparation of Enantiomerically Pure α-Amino Acid Derivatives from Aldimines and Tributyltin Cyanide or Achiral Aldehydes, Amines, and Hydrogen Cyanide Using a Chiral Zirconium Catalyst》 about this compound( cas:119707-74-3 ) in Journal of the American Chemical Society. Keywords: amino acid preparation asym Strecker imine aldehyde amine catalyst. We’ll tell you more about this compound (cas:119707-74-3).
Catalytic enantioselective Strecker-type reactions of aldimines with tributyltin cyanide (Bu3SnCN) proceeded smoothly in the presence of a novel chiral zirconium catalyst. High levels of enantioselectivities in the synthesis of α-amino nitrile derivatives with wide substrate generality were obtained via these reactions. In addition, hydrogen cyanide (HCN) was successfully used instead of Bu3SnCN as the cyanide source. Catalytic asym. Strecker amino acid synthesis starting from achiral aldehydes, amines, and HCN using a chiral zirconium catalyst has also been achieved. The three-component asym. process reported here significantly improves upon the original Strecker reaction, and has advantages over previous reactions using unstable imines (Schiff bases) as starting materials. Moreover, high yields and enantioselectivities have been obtained even in the reactions using aliphatic aldehydes, and both enantiomers of various types of α-amino acid derivatives can be prepared As demonstrations to show the utility of this reaction, efficient syntheses of homophenylalanine, leucine amide, and pipecolic acid derivatives have been performed. Finally, two novel binuclear zirconium complexes are postulated to be active chiral catalysts in the reactions of aldimines with Bu3SnCN and the three-component reactions, resp., and low loading levels of the chiral catalysts (1-2.5 mol %) have been accomplished in both cases.
Compounds in my other articles are similar to this one((S)-3,3′-Dibromo-1,1′-bi-2-naphthol)SDS of cas: 119707-74-3, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.
Reference:
Bromide – Wikipedia,
bromide – Wiktionary