So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Barnett, David S.; Moquist, Philip N.; Schaus, Scott E. researched the compound: (S)-3,3′-Dibromo-1,1′-bi-2-naphthol( cas:119707-74-3 ).Synthetic Route of C20H12Br2O2.They published the article 《The Mechanism and an Improved Asymmetric Allylboration of Ketones Catalyzed by Chiral Biphenols》 about this compound( cas:119707-74-3 ) in Angewandte Chemie, International Edition. Keywords: chiral BINOL catalyzed asym allylboration ketone mechanism catalyst exchange. We’ll tell you more about this compound (cas:119707-74-3).
The increase in both rate and enantioselectivity in the chiral BINOL-catalyzed asym. allylboration of PhCOMe with diiso-Pr allylboronate with addition of iso-PrOH was attributed to the exchange reaction of iso-PrOH with iso-Pr (S)-2-phenyl-4-pentenyl BINOL boronate, thus liberating product and starting catalyst. Use of a cyclic allylboronate (2-allyl-1,3,2-dioxaborinane) that would produce a tethered alc. upon catalyst exchange, facilitating catalyst release at end of reaction cycle, and in addition 2 equiv tBuOH relative to ketone, provided (S)-2-phenyl-4-penten-2-ol in near quant. yield and >99:1 e.r.; moreover, the reaction could be run in absence of solvent and the catalyst could be recovered in 90% yield from the reaction.
In some applications, this compound(119707-74-3)Synthetic Route of C20H12Br2O2 is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.
Reference:
Bromide – Wikipedia,
bromide – Wiktionary