Extracurricular laboratory: Synthetic route of 119707-74-3

In some applications, this compound(119707-74-3)Synthetic Route of C20H12Br2O2 is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Barnett, David S.; Moquist, Philip N.; Schaus, Scott E. researched the compound: (S)-3,3′-Dibromo-1,1′-bi-2-naphthol( cas:119707-74-3 ).Synthetic Route of C20H12Br2O2.They published the article 《The Mechanism and an Improved Asymmetric Allylboration of Ketones Catalyzed by Chiral Biphenols》 about this compound( cas:119707-74-3 ) in Angewandte Chemie, International Edition. Keywords: chiral BINOL catalyzed asym allylboration ketone mechanism catalyst exchange. We’ll tell you more about this compound (cas:119707-74-3).

The increase in both rate and enantioselectivity in the chiral BINOL-catalyzed asym. allylboration of PhCOMe with diiso-Pr allylboronate with addition of iso-PrOH was attributed to the exchange reaction of iso-PrOH with iso-Pr (S)-2-phenyl-4-pentenyl BINOL boronate, thus liberating product and starting catalyst. Use of a cyclic allylboronate (2-allyl-1,3,2-dioxaborinane) that would produce a tethered alc. upon catalyst exchange, facilitating catalyst release at end of reaction cycle, and in addition 2 equiv tBuOH relative to ketone, provided (S)-2-phenyl-4-penten-2-ol in near quant. yield and >99:1 e.r.; moreover, the reaction could be run in absence of solvent and the catalyst could be recovered in 90% yield from the reaction.

In some applications, this compound(119707-74-3)Synthetic Route of C20H12Br2O2 is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Bromide – Wikipedia,
bromide – Wiktionary