So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Kaur, Hardeep; Balzarini, Jan; de Kock, Carmen; Smith, Peter J.; Chibale, Kelly; Singh, Kamaljit researched the compound: 7-Chloro-4-(piperazin-1-yl)quinoline( cas:837-52-5 ).Electric Literature of C13H14ClN3.They published the article 《Synthesis, antiplasmodial activity and mechanistic studies of pyrimidine-5-carbonitrile and quinoline hybrids》 about this compound( cas:837-52-5 ) in European Journal of Medicinal Chemistry. Keywords: cyanopyridine quinoline preparation SAR antiplasmodial activity; 4-Aminoquinoline; Antiplasmodial agents; Cytotoxic activity; Heme binding; Hybrid antimalarials; Pyrimidine. We’ll tell you more about this compound (cas:837-52-5).
A series of hybrids I [R1 = H, 3-NO2, 4-Me, etc, R2 = SMe, morpholinyl; R3 = -NH(CH2)3NH-, -NH(CH2)4NH-, -O(CH2)3NH-, etc.] comprising of 5-cyanopyrimidine and quinoline moiety were synthesized and tested for in vitro antiplasmodial activity against NF54 and Dd2 strains of Plasmodium falciparum. Hybrid bearing m-nitrophenyl substituent at C-4 of pyrimidine displayed the highest antiplasmodial activity [IC50 = 56 nM] against the CQR (Dd2) strain, which is four-fold greater than CQ.
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Reference:
Bromide – Wikipedia,
bromide – Wiktionary