A new synthetic route of 17696-11-6

I hope my short article helps more people learn about this compound(8-Bromooctanoic acid)COA of Formula: C8H15BrO2. Apart from the compound(17696-11-6), you can read my other articles to know other related compounds.

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Schaeker-Huebner, Linda; Warstat, Robin; Ahlert, Heinz; Mishra, Pankaj; Kraft, Fabian B.; Schliehe-Diecks, Julian; Schoeler, Andrea; Borkhardt, Arndt; Breit, Bernhard; Bhatia, Sanil; Huegle, Martin; Guenther, Stefan; Hansen, Finn K. researched the compound: 8-Bromooctanoic acid( cas:17696-11-6 ).COA of Formula: C8H15BrO2.They published the article 《4-Acyl Pyrrole Capped HDAC Inhibitors: A New Scaffold for Hybrid Inhibitors of BET Proteins and Histone Deacetylases as Antileukemia Drug Leads》 about this compound( cas:17696-11-6 ) in Journal of Medicinal Chemistry. Keywords: antileukemia drug HDAC BET dual inhibitors BRD4 apoptosis anticancer. We’ll tell you more about this compound (cas:17696-11-6).

Multitarget drugs are an emerging alternative to combination therapies. In three iterative cycles of design, synthesis, and biol. evaluation, we developed a novel type of potent hybrid inhibitors of bromodomain, and extra-terminal (BET) proteins and histone deacetylases (HDACs) based on the BET inhibitor XD14 and well-established HDAC inhibitors. The most promising new hybrids, 49 and 61, displayed submicromolar inhibitory activity against HDAC1-3 and 6, and BRD4(1), and possess potent antileukemia activity. 49 induced apoptosis more effectively than the combination of ricolinostat and birabresib (1:1). The most balanced dual inhibitor, 61, induced significantly more apoptosis than the related control compounds 62 (no BRD4(1) affinity) and 63 (no HDAC inhibition) as well as the 1:1 combination of both. Addnl., 61 (I) was well tolerated in an in vivo zebrafish toxicity model. Overall, our data suggest an advantage of dual HDAC/BET inhibitors over the combination of two single targeted compounds

I hope my short article helps more people learn about this compound(8-Bromooctanoic acid)COA of Formula: C8H15BrO2. Apart from the compound(17696-11-6), you can read my other articles to know other related compounds.

Reference:
Bromide – Wikipedia,
bromide – Wiktionary