The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (2S)-1-[(4R)-4,5-dihydro-4-phenyl-2-oxazolyl]-2-(diphenylphosphino)ferrocene( cas:291536-01-1 ) is researched.Safety of (2S)-1-[(4R)-4,5-dihydro-4-phenyl-2-oxazolyl]-2-(diphenylphosphino)ferrocene.Zhang, Dan-Jie; Xie, Ming-Sheng; Qu, Gui-Rong; Gao, Yao-Wei; Guo, Hai-Ming published the article 《Synthesis of Azacyclic Nucleoside Analogs via Asymmetric [3+2] Cycloaddition of 9-(2-Tosylvinyl)-9H-purines》 about this compound( cas:291536-01-1 ) in Organic Letters. Keywords: azacyclic nucleoside synthesis asym stereoselective cycloaddition tosylvinylpurine copper catalyst. Let’s learn more about this compound (cas:291536-01-1).
With 9-(2-tosylvinyl)-9H-purines as the dipolarophiles, a series of chiral azacyclic nucleosides with four continuous stereo-centers were obtained in 86-99% yields, >20:1 dr, and 94 → 99% ee via the Cu(I)-catalyzed asym. [3+2] cycloaddition Both (E)- and (Z)-9-(2-tosylvinyl)-9H-purines were suitable dipolarophiles, enriching the structure diversity of azacyclic nucleosides. Furthermore, when α-Me imino ester was explored, the corresponding azacyclic nucleoside with a chiral quaternary stereo-center could also be afforded with excellent results.
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Reference:
Bromide – Wikipedia,
bromide – Wiktionary