Formula: C7H12O3. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Ethyl 3-Ethoxy-2-Propenoate, is researched, Molecular C7H12O3, CAS is 1001-26-9, about Regiospecific synthesis of cyclopentane analogs of (2′- and 3′-deoxy-threo-pentofuranosyl)uracil and -2-thiouracil nucleosides. Author is Hronowski, Lucjan J. J.; Szarek, Walter A..
The regiospecific synthesis of two new aminohydroxycyclopentanemethanols, I (R = H, R1 = OH; R = OH, R1 = H) is described. In these syntheses the desired configuration in the cyclopentane ring is obtained by opening the cyclopentanedicarboxylic acid anhydride II with either NH3 or MeOH. The attack by each nucleophile occurs at the carbonyl carbon furthest away from the acetoxy group to give a carbamoyl or an ester function at this position. Since the ester function is destined to become the hydroxymethyl substituent and the carbamoyl function the amino substituent, the type of nucleophile used to open the anhydride determines whether the 2-deoxy or the 3-deoxy isomer is obtained. Coupling of the aminohydroxycyclopentanemethanols with 3-ethoxypropenoyl isocyanate followed by cyclization of the acyl ureas in 2 N H2SO4 gave two new cyclopentane analogs of uracil nucleosides, e.g., III. Coupling of the aminohydroxycyclopentanemethanols with 3-ethoxypropenoyl isothiocyanate followed by cyclization of the acyl thioureas in 15 N aqueous NH3 gave two new cyclopentane analogs of 2-thiouracil nucleosides.
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Reference:
Bromide – Wikipedia,
bromide – Wiktionary