Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 33216-52-3, is researched, SMILESS is C1=NC=C(C(=C1Cl)Cl)Cl, Molecular C5H2Cl3NJournal, Tetrahedron called Microwave-assisted synthesis of 4-amino-3,5-dihalopyridines, Author is Pichowicz, Mark; Crumpler, Simon; McDonald, Edward; Blagg, Julian, the main research direction is amino halopyridine preparation; microwave assisted nucleophilic aromatic substitution halopyridine primary secondary amine.Application In Synthesis of 3,4,5-Trichloropyridine.
4-Amino-3,5-dihalopyridines have been efficiently prepared via microwave-assisted nucleophilic aromatic substitution of 3,4,5-trihalopyridines using 1-1.1 equiv of primary and secondary amines. The reaction is also applicable to electron rich arylamines.
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Reference:
Bromide – Wikipedia,
bromide – Wiktionary