The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 6-Bromo-3-methyl-1H-indole(SMILESS: CC1=CNC2=C1C=CC(Br)=C2,cas:1219741-50-0) is researched.Related Products of 60827-45-4. The article 《Facile synthesis of 9H-pyrrolo[1,2-a]indoles via Bronsted acid catalyzed cascade reactions》 in relation to this compound, is published in Chemical Communications (Cambridge, United Kingdom). Let’s take a look at the latest research on this compound (cas:1219741-50-0).
An efficient Bronsted acid catalyzed Friedel-Crafts alkenylation/1,6-addition/condensation cascade reaction has been developed. This protocol enables effective access to various highly functionalized 9H-pyrrolo[1,2-a]indoles I (R1 = Bu, 3-chlorophenyl, thiophen-2-yl, etc.; R2 = Me, thiophen-2-yl, naphthalen-1-yl, etc.; R3 = H, 7-Me, 8-MeO, 6-F, etc.; R4 = Me, phenyl; R5 = H, 6-Cl, 7-MeO, etc.) in moderate to high yields. Mechanistic studies indicate that the in situ vinylogous reactivity intermediate might be formed in the catalytic system.
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Reference:
Bromide – Wikipedia,
bromide – Wiktionary