Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 33216-52-3, is researched, Molecular C5H2Cl3N, about Reissert compound studies. XLIX. An improved synthesis of the pyridine Reissert analog and its utilization in the regiospecific preparation of 2-substituted pyridines, the main research direction is pyridine Reissert compound preparation alkylation; alkylpyridine; pyridylphenylcarbinol; oxazolopyridine.Formula: C5H2Cl3N.
Pyridine Reissert compounds I [R = H(II), 3-CN, 2-PhCH2, 3-Me, 4-Me, R1 = H] were prepared by stirring pyridines in CH2Cl2 at room temperature with equimolar amounts of Me3SiCN and ClCO2Et in the presence of AlCl3. Addition of NaH to II in DMF at 0° gave carbanion III, which was alkylated with alkyl halides to give I (R1 = Me, Et, PhCH2), treatment of which in HMPT at 100-120° with NaI gave the corresponding 2-alkylpyridines. Pyridinecarbinols IV (R2 = H, Me) were prepared by condensation of 2-R2C6H4CHO with III, and oxazolopyridine V was obtained by treatment of II with BuLi in THF at -78° in the presence of PhCHO.
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Reference:
Bromide – Wikipedia,
bromide – Wiktionary