Month: March 2022

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Visible-light-induced metathesis reaction between diselenide and ditelluride, published in 2019, which mentions a compound: 17696-11-6, mainly applied to diselenide ditelluride metathesis reaction kinetics radical mechanism, Quality Control of 8-Bromooctanoic acid.

The Se-Te bond was prepared by a metathesis reaction between diselenides and ditellurides, which could be manipulated with the presence or absence of visible light. Addnl., the apparent activation energy of the exchange process was measured to be only 28.01 kJ mol-1, explaining the high reactivity and sensitivity to light.

If you want to learn more about this compound(8-Bromooctanoic acid)Quality Control of 8-Bromooctanoic acid, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(17696-11-6).

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Safety of 7-Chloro-4-(piperazin-1-yl)quinoline. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 7-Chloro-4-(piperazin-1-yl)quinoline, is researched, Molecular C13H14ClN3, CAS is 837-52-5, about Development of a lateral flow dipstick for simultaneous and semi-quantitative analysis of dihydroartemisinin and piperaquine in an artemisinin combination therapy. Author is Ning, Xiangxue; Tan, Guiyu; Chen, Xiaojiao; Wang, Mian; Wang, Baomin; Cui, Liwang.

Dihydroartemisinin (DHA) and piperaquine (PPQ) are two drugs used in an artemisinin-based combination therapy (ACT). The circulation of counterfeit antimalarial drugs demands the development of simple, point-of-care (POC) tests for monitoring drug quality. Here we aimed to design an antibody-based lateral flow dipstick assay for simultaneous quality control of DHA and PPQ. To obtain a monoclonal antibody (mAb) for PPQ, one structural unit of the sym. PPQ mol. was used to derive a carboxylic acid for linkage to a carrier protein as immunogen. Screening of hybridoma cells identified an mAb 4D112B2 that reacted with the PPQ-based immunogen. A highly-sensitive icELISA was designed based on this mAb, which showed 50% inhibition concentration of PPQ at 1.66 ng/mL and a working range of 0.35 – 7.40 ng/mL. The mAb showed 10.2, 15.9 and 30.4% cross reactivity to hydroxychloroquine sulfate, chloroquine and amodiaquine, resp. No cross reactivity was observed to lumefantrine, mefloquine artemisinin and its derivatives Using our previous DHA dipstick design, a lateral flow dipstick for simultaneous anal. of PPQ and DHA was developed. The indicator ranges for PPQ and DHA were 2 – 5μg/mL and 250 – 500 ng/mL, resp. The dipstick was used to semi-quant. analyze PPQ and DHA content in com. ACT drugs, which produced agreeable results to those determined by high-performance liquid chromatog. This combination dipstick makes it a potential POC device for quality control of the two active ingredients in a commonly used ACT.

If you want to learn more about this compound(7-Chloro-4-(piperazin-1-yl)quinoline)Safety of 7-Chloro-4-(piperazin-1-yl)quinoline, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(837-52-5).

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called The electrosynthesis of gold(I) complexes: A clean, one-pot method, published in 2020-01-31, which mentions a compound: 286014-53-7, mainly applied to gold complex one pot electrosynthesis, Synthetic Route of C21H25BF4N2.

Gold complexes are emerging as promising compounds in a range of applications. Synthetic methods for producing these complexes involve multiple steps, the use of reducing agents, inert atm. techniques and transmetallation reactions, resulting in contaminated products and low yields. Here we demonstrate, for the first time, a clean, one-pot electrosynthesis method which produces gold(I)-N-heterocyclic carbenes and gold(I)-bis-phosphine by the anodic corrosion of a polycrystalline gold electrode in a solution containing the ligands and the electrolyte. The electrochem. reactions require only electrons and, therefore, the production of the complexes starts from the zero-valent metal, avoiding contamination with other metals, as is the case in transmetallation reactions, or byproducts generated by the use of reducing agents.

If you want to learn more about this compound(1,3-Dimesityl-1H-imidazol-3-ium tetrafluoroborate)Synthetic Route of C21H25BF4N2, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(286014-53-7).

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Recommanded Product: 3,4,5-Trichloropyridine. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 3,4,5-Trichloropyridine, is researched, Molecular C5H2Cl3N, CAS is 33216-52-3, about A simple and efficient method for the preparation of pyridine N-oxides. II. Author is Coperet, Christophe; Adolfsson, Hans; Chiang, Jay P.; Yudin, Andrei K.; Sharpless, K. Barry.

Oxidation of pyridines with bis(trimethylsilyl) peroxide in the presence of catalytic amounts of inorganic Re derivatives gives high yields of their anal. pure N-oxides by simple work-ups, typically a filtration or a Kugelrohr distillation

If you want to learn more about this compound(3,4,5-Trichloropyridine)Recommanded Product: 3,4,5-Trichloropyridine, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(33216-52-3).

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Efficient Synthesis of a Trisubstituted 1,6-Naphthyridone from Acetonedicarboxylate and Regioselective Suzuki Arylation, published in 2005-12-09, which mentions a compound: 1001-26-9, Name is Ethyl 3-Ethoxy-2-Propenoate, Molecular C7H12O3, Related Products of 1001-26-9.

An efficient five-step synthesis of 1,6-naphthyridone I, a p38 mitogen-activated protein (MAP) kinase inhibitor intermediate, in 32% overall yield starting from acetonedicarboxylate (ADC) is described. The synthesis began with a selective monoamidation of ADC di-Me ester enolate. A novel concomitant enamine formation and an imide cyclization afforded the nitrogen differentially protected enamide imide. Treatment of this with KOCMe3 and 3-ethoxyacrylate produced lactam quant., which was converted to tetrachloronaphthyridone via a one-pot p-methoxybenzyl deprotection and bischlorination. A highly regioselective Pd(OAc)2/IMes-catalyzed Suzuki coupling completed the synthesis.

If you want to learn more about this compound(Ethyl 3-Ethoxy-2-Propenoate)Related Products of 1001-26-9, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(1001-26-9).

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Optimization of pyrazolo[1,5-a]pyrimidines lead to the identification of a highly selective casein kinase 2 inhibitor, published in 2020-12-15, which mentions a compound: 1001-26-9, Name is Ethyl 3-Ethoxy-2-Propenoate, Molecular C7H12O3, HPLC of Formula: 1001-26-9.

Casein kinase 2 (CK2) is a constitutively expressed serine/threonine kinase that has a large diversity of cellular substrates. Thus, CK2 has been associated with a plethora of regulatory functions and dysregulation of CK2 has been linked to disease development in particular to cancer. The broad implications in disease pathol. makes CK2 an attractive target. To date, the most advanced CK2 inhibitor is silmitasertib, which has been investigated in clin. trials for treatment of various cancers, albeit several off-targets for silmitasertib have been described. To ascertain the role of CK2 inhibition in cancer, other disease and normal physiol. the development of a selective CK2 inhibitor would be highly desirable. In this study we explored the pyrazolo [1,5-a]pyrimidine hinge-binding moiety for the development of selective CK2 inhibitors. Optimization of this scaffold, which included macrocyclization, led to IC20 (31) a compound that displayed high in vitro potency for CK2 (KD = 12 nM) and exclusive selectivity for CK2. X-ray anal. revealed a canonical type-I binding mode for IC20 (31). However, the polar carboxylic acid moiety that is shared by many CK2 inhibitors including silmitasertib was required for potency but limits the cellular activity of IC20 (31) and the cellular IC50 dropped to the low micromolar range. In summary, IC20 (31) represents a highly selective and potent inhibitor of CK2, which can be used as a tool compound to study CK2 biol. and potential new applications for the treatment of diseases.

If you want to learn more about this compound(Ethyl 3-Ethoxy-2-Propenoate)HPLC of Formula: 1001-26-9, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(1001-26-9).

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 1001-26-9, is researched, SMILESS is O=C(OCC)/C=C/OCC, Molecular C7H12O3Journal, Heterocycles called Palladium-catalyzed cross-coupling of aryl iodides with ethyl 2-ethoxy- and 3-ethoxyacrylate, Author is Sakamoto, Takao; Kondo, Yoshinori; Kashiwagi, Yoshitomo; Yamanaka, Hiroshi, the main research direction is coupling iodoquinoline acrylate catalyst; iodopyridine coupling acrylate catalyst; iodobenzene coupling acrylate catalyst; quinolinylacrylic acid; cinnamate ester.Quality Control of Ethyl 3-Ethoxy-2-Propenoate.

The reaction of 3-iodoquinoline with R1CH:CR2CO2Et (one at R1 and R2 is OEt and the other is H), Pd, and K2CO3 in MeCN gave Et 3-quinolylacrylates I. Similarly prepared were pyridylacrylate esters II and 4-R3C6H4CR1:CR2CO2Et (R3 = H, OMe).

If you want to learn more about this compound(Ethyl 3-Ethoxy-2-Propenoate)Quality Control of Ethyl 3-Ethoxy-2-Propenoate, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(1001-26-9).

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Vibration and electronic spectra of esters of polyenecarboxylic acids》. Authors are Kogan, G. A.; Ivanova, T. M.; Yanovskaya, L. A.; Kucherov, V. F.; Popov, E. M..The article about the compound:Ethyl 3-Ethoxy-2-Propenoatecas:1001-26-9,SMILESS:O=C(OCC)/C=C/OCC).Formula: C7H12O3. Through the article, more information about this compound (cas:1001-26-9) is conveyed.

The frequencies and integral intensities of bands in the ir and uv spectra and Raman spectra of polyene compounds X(CH:CH)nCOOEt (X = Me, OEt, COH, NO2, and CO2Et; n = 1-5) were investigated in a study of the mutual effect of functional groups of atoms through a system of conjugate bonds. Causes of changes in these parameters in the spectra of compounds in the basic and excited states were determined from an analysis of the data.

If you want to learn more about this compound(Ethyl 3-Ethoxy-2-Propenoate)Formula: C7H12O3, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(1001-26-9).

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Computed Properties of C13H14ClN3. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 7-Chloro-4-(piperazin-1-yl)quinoline, is researched, Molecular C13H14ClN3, CAS is 837-52-5, about Synthesis of hydroxypiperaquine, an antimalarial drug. Author is Thai, Hoang; Nguyen, Thac Kim; Nguyen, The Anh.

Piperaquine has been effectively used in combination with dihydroartemisinin for the treatment of the CQ-resistant malaria in Vietnam. At present, this compound is synthesized in our laboratory on multikilogram scale for making the drug artekin for the treatment of malaria. In this paper, we describe the synthesis of hydroxypiperaquine, a derivative of piperaquine. Hydroxypiperaquine is a known antimalarial drug. Hydroxypiperaquine was synthesized by two methods. In the first method, hydroxypiperaquine was synthesized in 50% yield by treatment of two equivalent of 7-chloro-4-(piperazin-1-yl)quinoline with one equivalent of epichlorohydrin. In the second method, hydroxpiperaquine was obtained in 70% yield by reaction of 7-chloro-4-(piperazin-1-yl)quinoline with 1-chloro-3-[4-(7-chloroquinolin-4-yl)piperazin-1-yl]propan-2-ol. The structures of the intermediates and hydroxypiperaquine were reconfirmed by IR, MS and NMR spectra.

If you want to learn more about this compound(7-Chloro-4-(piperazin-1-yl)quinoline)Computed Properties of C13H14ClN3, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(837-52-5).

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Twist-Bend Nematic Glasses: The Synthesis and Characterisation of Pyrene-based Nonsymmetric Dimers, published in 2021-03-01, which mentions a compound: 17696-11-6, mainly applied to pyrene liquid crystal dimer preparation twist bend nematic phase; glassy phase; liquid crystals; pyrene; spontaneous chirality; twist-bend nematic, Electric Literature of C8H15BrO2.

A selection of pyrene-based liquid crystal dimers I [n = 5, 6, 8, etc.] , II [n = 5, 6, 11, etc.] and III were prepared, containing either methylene-ether or diether linked spacers of varying length and parity. All the diether linked materials, II, exhibited conventional nematic and smectic A phases, with the exception of II [n = 11] which was exclusively nematic. The methylene-ether linked dimer, I with an even-membered spacer (n=5) was solely nematogenic, but odd-members (n=6, 8, 10) exhibited both nematic and twist-bend nematic phases. Replacement of the cyanobiphenyl fragment by cyanoterphenyl giving III, gave elevated melting and nematic-isotropic transition temperatures, and SmA and SmCA phases were observed on cooling the nematic phase. Intermol. face-to-face associations of the pyrene moieties drove glass formation, and all these materials had a glass transition temperature at or above room temperature The stability of the glassy twist-bend nematic phase allowed for its study using AFM, and the helical pitch length, PTB, was measured as 6.3 and 6.7 nm for I [n = 6, 8] , resp. These values were comparable to the shortest pitch of a twist-bend nematic phase measured to date.

If you want to learn more about this compound(8-Bromooctanoic acid)Electric Literature of C8H15BrO2, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(17696-11-6).

Reference:
Bromide – Wikipedia,
bromide – Wiktionary