Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 837-52-5, is researched, SMILESS is C1=C(Cl)C=C2C(=C1)C(=CC=N2)N3CCNCC3, Molecular C13H14ClN3Journal, Article, Research Support, Non-U.S. Gov’t, European Journal of Medicinal Chemistry called Squaric acid/4-aminoquinoline conjugates: Novel potent antiplasmodial agents, Author is Ribeiro, Carlos J. A.; Kumar, S. Praveen; Gut, Jiri; Goncalves, Lidia M.; Rosenthal, Philip J.; Moreira, Rui; Santos, Maria M. M., the main research direction is squaric acid aminoquinoline conjugate preparation antiplasmodial SAR; 4-Aminoquinoline; Antiplasmodial activity; Hybrid; Malaria; Squaramide.Related Products of 837-52-5.
We report the synthesis and structure-activity relationship (SAR) anal. of a series of hybrid compounds containing a squaric moiety conjugated with heterocyclic moieties from well-known antimalarials. This novel series of compounds presents improved antiplasmodial activity compared with the squaric derivatives described in our previous work. Three compounds, I (n = 3, IC50 = 99 nM; n = 4, IC50 = 95 nM) and II (IC50 = 105 nM) had greater in vitro potency than chloroquine (IC50 = 140 nM) against chloroquine resistant Plasmodium falciparum. In addition, they were noncytotoxic against NIH 3T3 and Hek 293T cells.
Here is a brief introduction to this compound(837-52-5)Related Products of 837-52-5, if you want to know about other compounds related to this compound(837-52-5), you can read my other articles.
Reference:
Bromide – Wikipedia,
bromide – Wiktionary