The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 7-Chloro-4-(piperazin-1-yl)quinoline, is researched, Molecular C13H14ClN3, CAS is 837-52-5, about Piperazinyl quinolines as chemosensitizers to increase fluconazole susceptibility of Candida albicans clinical isolates, the main research direction is piperazinyl quinoline Candida fluconazole sensitivity.Recommanded Product: 837-52-5.
The effectiveness of the potent antifungal drug fluconazole is being compromised by the rise of drug-resistant fungal pathogens. While inhibition of Hsp90 or calcineurin can reverse drug resistance in Candida, such inhibitors also impair the homologous human host protein and fungal-selective chemosensitizers remain rare. The MLPCN library was screened to identify compounds that selectively reverse fluconazole resistance in a Candida albicans clin. isolate, while having no antifungal activity when administered as a single agent. A piperazinyl quinoline was identified as a new small-mol. probe (ML189) satisfying these criteria.
There is still a lot of research devoted to this compound(SMILES：C1=C(Cl)C=C2C(=C1)C(=CC=N2)N3CCNCC3)Recommanded Product: 837-52-5, and with the development of science, more effects of this compound(837-52-5) can be discovered.
Reference:
Bromide – Wikipedia,
bromide – Wiktionary