Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 17696-11-6, is researched, SMILESS is O=C(O)CCCCCCCBr, Molecular C8H15BrO2Journal, European Polymer Journal called Alkynyl-functionalized chain-extended PCL for coupling to biological molecules, Author is Izraylit, Victor; Hommes-Schattmann, Paul J.; Neffe, Axel T.; Gould, Oliver E. C.; Lendlein, Andreas, the main research direction is alkynyl chain extended caprolactone polymer biol mol.COA of Formula: C8H15BrO2.
Chem. functionalization of poly(ε-caprolactone) (PCL) enables a mol. integration of addnl. function. Here, the authors report an approach to incorporate reactive alkynyl side-groups by synthesizing a chain-extended PCL, where the reactive site is introduced through the covalently functionalizable chain extender 3-(prop-2-yn-1-yloxy)propane-1,2-diol (YPD). Chain-extended PCL with Mw of 101 to 385 kg·mol-1 were successfully synthesized in a one-pot reaction from PCL-diols with various molar masses, L-lysine Et ester diisocyanate (LDI) or trimethyl(hexamethylene)diisocyanate (TMDI), and YPD, in which the d. of functionalizable groups and spacing between them can be controlled by the composition of the polymer. The employed diisocyanate compounds and YPD possess an asym. structure and form a non-crystallizable segment leaving the PCL crystallites to dominate the material′s mech. properties. The mixed glass transition temperature Tg = -60 to -46° of the PCL/polyurethane amorphous phase maintains the synthesized materials in a highly elastic state at ambient and physiol. conditions. Reaction conditions for covalent attachment in copper(I)-catalyzed azide-alkyne-cycloaddition reactions (CuAAC) in solution were optimized in a series of model reactions between the alkyne moieties of the chain-extended PCL and benzyl azide, reaching conversions over 95% of the alkyne moieties and with yields of up to 94% for the purified functionalized PCL. This methodol. was applied for reaction with the azide-functionalized cell adhesion peptide GRGDS. The required modification of the peptide provides selectivity in the coupling reactions. The obtained results suggest that YPD could potentially be employed as versatile mol. unit for the creation of a variety of functionalizable polyesters as well as polyurethanes and polycarbonates offering efficient and selective click-reactions.
Here is a brief introduction to this compound(17696-11-6)COA of Formula: C8H15BrO2, if you want to know about other compounds related to this compound(17696-11-6), you can read my other articles.
Reference:
Bromide – Wikipedia,
bromide – Wiktionary