Synthetic Route of 2550-36-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2550-36-9, name is (Bromomethyl)cyclohexane, This compound has unique chemical properties. The synthetic route is as follows.
4-(4-chlorophenyl)-1 -(2-methoxyethyl)-6-methyl-2-oxo-3,4-dihydropyridine-5-carboxylic acid (example 74, 75 mg, 0.23 mmol) was dissolved in anhydrous DMF (1 mL) then cesium carbonate (1 14 mg, 0.35 mmol) and cyclohexylmethylbromide (49 muIota_, 0.35 mmol) were added. The reaction mixture was stirred at 50 C for 24 h. The solvent was removed under reduced pressure. The residue was dissolved in EtOAc and water. The aqueous phase was extracted with EtOAc. The organic layers were assembled, washed with brine and dried over MgS04. The solvent was removed under reduced pressure to give the desired [cyclohexylmethyl 4-(4- chlorophenyl)-1 -(2-methoxyethyl)-6-methyl-2-oxo-3,4-dihydropyridine-5-c a r b o x y l a t e a s a yellowish oil (95 mg, 99 %). 1 H N MR (300 MHz, CDCI3) delta 0.71 -1 .18 (m, 5H), 1 .46-1 .63 (m, 6H), 2.61 (s, 3H), 2.71 (dd, J = 15.7, 2.3 Hz, 1 H), 2.92 (dd, J = 15.7, 7.5 Hz, 1 H), 3.32 (s, 3H), 3.38 (ddd, J = 9.8, 8.5, 3.7 Hz, 1 H), 3.47 (dt, J = 9.8, 3.9 Hz, 1 H), 3.75 (ddd, J = 14.6, 8.5, 3.9 Hz, 1 H), 3.81 -3.91 (m, 2H), 4.13-4.21 (m, 2H), 7.1 1 (d, J = 8.5 Hz, 2H), 7.22 (d, J = 8.5 Hz, 2H). MS [M+H]+ 420. HRMS : calcd for C23H3i N04CI, [M+H]+ 420.1942, found 420.1937.
The chemical industry reduces the impact on the environment during synthesis (Bromomethyl)cyclohexane. I believe this compound will play a more active role in future production and life.
Reference:
Patent; UNIVERSITE DE LILLE 2 DROIT ET SANTE; INSTITUT PASTEUR DE LILLE; INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE); CHARTON, Julie; DEPREZ, Benoit; LEROUX, Florence; STAELS, Bart; MUHR-TAILLEUX, Anne; HENNUYER, Nathalie; LESTAVEL, Sophie; PICON, Sylvain; AKNIN, Karen; BOULAHJAR, Rajaa; DUBANCHET, Barbara; (234 pag.)WO2016/16238; (2016); A1;,
Bromide – Wikipedia,
bromide – Wiktionary