23-Sep-2021 News Sources of common compounds: 129316-09-2

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,3-Dibromo-5-(tert-butyl)benzene, other downstream synthetic routes, hurry up and to see.

Electric Literature of 129316-09-2, The chemical industry reduces the impact on the environment during synthesis 129316-09-2, name is 1,3-Dibromo-5-(tert-butyl)benzene, I believe this compound will play a more active role in future production and life.

Step 1 : 1-(3-Bromo-5-(te t-butyl)phenyl)ethanone (P49a) To a solution of 1 ,3-dibromo-5-(fert-butyl)benzene (664 mg, 2.22 mmol) in toluene (15 mL) were added tri-n-butyl-1-ethoxyvinyl tin (965 mg, 2.66 mmol) and Pd(PPh3)2CI2 (150 mg 0.22 mmol) under N2. The mixture was stirred at 95C for 3 h, evaporated, diluted with 1 ,4-dioxane and 2N HCI, stirred rapidly at 25C for 1h and then extracted with EA. The combined organic layers were washed with brine, dried over Na2S04, concentrated and purified by CC to afford compound P49a (310 mg, 55%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,3-Dibromo-5-(tert-butyl)benzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; PHENEX PHARMACEUTICALS AG; STEENECK, Christoph; KINZEL, Olaf; GEGE, Christian; KLEYMANN, Gerald; HOFFMANN, Thomas; WO2012/139775; (2012); A1;,
Bromide – Wikipedia,
bromide – Wiktionary