In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 937046-98-5, name is 7-Bromopyrrolo[2,1-f][1,2,4]triazin-4-amine belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. COA of Formula: C6H5BrN4
To a solution of Intermediate B (195 mg, 0.91 mmol) in THF at -78 0C under N2 was added dropwise n-butyllithium (1.46 ml, 3.66 mmol). The reaction mixture was stirred for 15 min and then gaseous ethylene oxide was bubbled into the reaction mixture for 5 min. The diy-ice bath was removed and warmed up to rt. Analytical HPLC found a new peak and then the reaction was quenched with 2 ml saturated aq NH4Cl followed by addition of 10 ml EtOAc and H2O (2ml). The organic phase was collected and washed with brine and dried over Na2SO4 and evaporated to crude as yellow oil. The crude was dissolved in 5 ml 10%MeOH/CH2Cl2 and 4 ml silica gel was added and then solvent evaporated. The crude in the silica gel was loaded on an MPLC column and was eluted with a gradient 0 – 10%MeOH in CH2Cl2 to give 20 mg of the desired product. ; MS [M+H]+ = 178.9; LCMS RT = 1.1 min
The synthetic route of 937046-98-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BAYER PHARMACEUTICALS CORPORATION; WO2007/64931; (2007); A2;,
Bromide – Wikipedia,
bromide – Wiktionary