Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 58534-95-5, name is 3-Bromo-2-fluoroaniline, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 3-Bromo-2-fluoroaniline
The product from step 1 (200 mg, 0.7268 mmol), 3-bromo-2-fluoro-phenylamine (165 mg, 0.7268 mmol, 1 eq.), Na2CO3 (616 mg, 5.814 mmol. 8 eq.) and Pd(PPh3)4 (84 mg, 0.1 eq.) are partially dissolved in a mixture of DMF (10 mL) and H2O (2 mL). N2 gas is bubbled through this reaction mixture for 5 minutes. The resulting mixture is heated to 150 C. in a sealed tube under microwave irradiation for 10 min. The reaction is diluted with EtOAc and sequentially washed with H2O, 1 N NaOH (aq), and saturated aqueous NaCl. The organic solution is dried over Na2SO4 and concentrated. The resulting residue is purified on silica gel (2:1 hexanes/EtOAc) to afford the aniline product as a yellow oil. ESMS m/z 259.1 (M+H+).
According to the analysis of related databases, 58534-95-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Irm LLC; US2009/75996; (2009); A1;,
Bromide – Wikipedia,
bromide – Wiktionary