Adding a certain compound to certain chemical reactions, such as: 149910-98-5, name is 7-Bromoisochroman, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 149910-98-5, Formula: C9H9BrO
Into a 500-mL round-bottom flask, was placed 7-bromoisochroman (8.48 g, 40.0 mmol, 1.0 equiv) in dioxane (200 mL)/water (20 mL). Pd(dppf)Cl2 (5.8 g, 8.0 mmol, 0.2 equiv) and CS2CO3 (26.1 g, 80.0 mmol, 2.0 equiv) (BPin)2 (2.5 eq) were added to the solution. The resulting solution was stirred for 16 hr at 90 degrees C, after which it was concentrated and purified with SiCk-gel column chromatography. This resulted in 4.6 g (44.2%) of 2-(isochroman-6-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane as a white solid.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 7-Bromoisochroman, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; NOVARTIS INFLAMMASOME RESEARCH, INC.; GLICK, Gary; ROUSH, William; VENKATRAMAN, Shankar; SHEN, Dong-Ming; GHOSH, Shomir; SEIDEL, Hans Martin; FRANCHI, Luigi; WINKLER, David Guenther; OPIPARI, Anthony William Jr.; KATZ, Jason; (468 pag.)WO2020/10140; (2020); A1;,
Bromide – Wikipedia,
bromide – Wiktionary