Reference of 10485-09-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 10485-09-3, name is 2-Bromoindene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Production Example 1 Synthesis of a Li salt of 2,2′-diindenyldimethylsilane In a 200 ml-two-neck flask, THF (10 ml) and Mg (2.5g, 1.0 mmol) were incorporated. Further, 1,2-dibromoethane (0.1 ml) was added. The resultant was stirred at room temperature for 10 minutes, whereby the Mg surface was activated. To this, 2-bromoindene (5.0g, 26 mmol) which had been dissolved in THF (40 ml) was added dropwise by means of a pressure equalizing funnel. The resulting reaction mixture was cooled on ice bath, and then, dichlorodimethylsilane (29.7 ml, 246 mmol) was added dropwise. After stirring the reaction mixture for overnight, the solvent was distilled off. Extraction was conducted from the resulting solid by using hexane (50 ml * 2). By subjecting the resulting extraction solution to evaporation dryness, 2,2′-diindenyldimethylsilane was obtained as a pale yellow oily product (3.47g, 12.0 mmol, 94%).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromoindene, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Idemitsu Kosan Co., Ltd.; YABUGAMI, Minoru; OKAMOTO, Takuji; EP2650300; (2013); A1;,
Bromide – Wikipedia,
bromide – Wiktionary