Application of 393-37-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 393-37-3, name is 5-Bromo-2-fluorobenzotrifluoride, This compound has unique chemical properties. The synthetic route is as follows.
A solution of methyl 2-(3-hydroxyphenyl)acetate (23.4 g, 141 mmol), 5-bromo-2- fluorobenzotrifluoride (44.5 g, 183.3 mmol) and cesium carbonate (91.9 g, 282 mmol) in DMF (250 mL) was stirred at 100 C for 5-7 h. After completion of the reaction, it was cooled to room temperature and diluted using water (1 1). Extraction was carried out using EtOAc (300 mL x 3); the combined organic layers were washed with water (500 mL x 3); brine (500 mL); dried over anhydrous Na2S04, filtered and concentrated under reduced pressure. The residue obtained was purified using silica gel column chromatography (product eluted using 5-10% EtOAc in hexane) to provide desired intermediate II-A-1 (30 g, 55% yield). 1H NMR (DMSO- d6 400 MHz) 3.62(s, 3H); 3.72 (s, 2H); 6.95-7.01 (aromatics, 2H); 7.02-7.06 (aromatics, 1H); 7.14 (d, J = 8.0 Hz, 1H); 7.37-7.41 (aromatics, 1H); 7.84 (dd, Jl = 2.7 Hz, J2 = 9.2 Hz, 1H); 7.95 (d, J = 2.7 Hz, 1H).
The chemical industry reduces the impact on the environment during synthesis 5-Bromo-2-fluorobenzotrifluoride. I believe this compound will play a more active role in future production and life.
Reference:
Patent; IMPETIS BIOSCIENCES LIMITED; SHAIKH, Nadim; THAKKAR, Mahesh; SHINDE, Shailesh; JOSHI, Manoj; NAIK, Keshav; BHALERAO, Amit; MUKIM, Mayur; BHUNIYA, Debnath; KULKARNI, Bheemashankar; MOOKHTIAR, Kasim; (115 pag.)WO2018/167800; (2018); A1;,
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