Application of 73918-56-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 73918-56-6, name is 2-(4-Bromophenyl)ethanamine, This compound has unique chemical properties. The synthetic route is as follows.
Step (i) of Reference Example 4: N-(4-Bromophenethyl)-2-nitrobenzenesulfonamide Triethylamine 0.7 ml (5.0 mmol) was added to a solution of 500 mg (2.5 mmol) of 2-(4-bromophenyl)ethanamine in tetrahydrofuran (5 ml). 2-Nitrobenzenesulfonyl chloride (664.6 mg, 3.0 mmol) was then added thereto, and the mixture was stirred at room temperature for one hr. Thereafter, a saturated aqueous sodium hydrogencarbonate solution was added thereto, and the mixture was then extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate and was then filtered. The filtrate was concentrated under the reduced pressure. The residue was purified by column chromatography on silica gel (hexane : ethyl acetate = 3 : 1) to give 915 mg (yield 95%) of the title compound. 1H-NMR (400 MHz, CDCl3) delta: 2.80 (2H, t, J = 6.8 Hz), 3.40 (2H, dt, J = 5.9, 6.8 Hz), 5.34 (1H, t, J = 5.8 Hz), 6.97 (2H, ddd, J = 1.9, 2.7, 8.3 Hz), 7.31 (2H, ddd, J = 1.9, 2.7, 8.3 Hz), 7.70 (1H, dt, J = 1.7, 7.6 Hz), 7.74 (1H, dt, J = 1.7, 7.6 Hz), 7.81-7.86 (1H, m), 8.01-8.05 (1H, m).
The chemical industry reduces the impact on the environment during synthesis 2-(4-Bromophenyl)ethanamine. I believe this compound will play a more active role in future production and life.
Reference:
Patent; Meiji Seika Kaisha Ltd.; EP2151447; (2010); A1;,
Bromide – Wikipedia,
bromide – Wiktionary